170863-34-0
- 产品名称：(ALPHAR,BETAR)-BETA-(2,4-二氟苯基)-BETA-羟基-ALPHA-甲基-1H-1,2,4-三唑-1-丁烷硫代酰胺
- 分子式：C13H14F2N4OS
- 纯度：99%
- 分子量：312.343
产品详情
- Molecular Formula:C13H14F2N4OS
- Molecular Weight:312.343
- Boiling Point:536.4±60.0 °C(Predicted)
- PKA:11.74±0.29(Predicted)
- PSA：113.59000
- Density:1.43±0.1 g/cm3(Predicted)
- LogP:2.08700
170863-34-0 Relevant articles
AN IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOLE DERIVATIVES
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, (2021/12/31)
The present invention relates to an impr...
An enantioselective synthesis of the key intermediate for triazole antifungal agents; Application to the catalytic asymmetric synthesis of efinaconazole (jublia)
Tamura, Keiji,Kumagai, Naoya,Shibasaki, Masakatsu
, p. 3272 - 3278 (2014/05/06)
A new synthetic route, the shortest repo...
Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
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Page/Page column 9, (2011/04/25)
A new technical process for preparation ...
Improved chiral synthesis of ravuconazole
Xu, Lin,Muller, Marc R.,Yu, Xiong,Zhu, Bao-Quan
experimental part, p. 1611 - 1625 (2009/10/17)
A short, elegant, and high yielding synt...
170863-34-0 Process route
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- 170862-36-9
(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile
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- 170863-34-0
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
| Conditions | Yield |
|---|---|
|
With O,O-Diethyl hydrogen phosphorodithioate; In water; isopropyl alcohol; Heating;
|
81% |
|
With O,S-diethyl-dithiophosphoric acid; In water; isopropyl alcohol; for 3h; Heating;
|
81% |
|
With diammonium sulfide; In ethanol; at 20 - 50 ℃;
|
|
|
With O,O-Diethyl hydrogen phosphorodithioate; In water; for 0.5h; Heating / reflux;
|
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(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide (1R)-10-camphorsulfonate
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- 170863-34-0
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
| Conditions | Yield |
|---|---|
|
With sodium hydrogencarbonate; In dichloromethane; water;
|
170863-34-0 Upstream products
-
170862-36-9
(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile
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135270-13-2
1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole
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132507-89-2
(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol
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60899-79-8
diethyl dithiophosphate
170863-34-0 Downstream products
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182760-06-1
ravuconazole
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170863-35-1
(2R,3R)-2-(2,4-Difluoro-phenyl)-3-[4-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-1-[1,2,4]triazol-1-yl-butan-2-ol
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368421-60-7
4-{2-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-thiazol-4-yl}-thiobenzamide
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207224-83-7
(2R,3R)-2-(2,4-Difluoro-phenyl)-1-[1,2,4]triazol-1-yl-3-{4-[4-(1H-[1,2,4]triazol-3-yl)-phenyl]-thiazol-2-yl}-butan-2-ol
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