170862-36-9
- 产品名称：(ALPHAS,BETAR)-BETA-(2,4-二氟苯基)-BETA-羟基-ALPHA-甲基-1H-1,2,4-三唑-1-丁腈
- 分子式：C13H12F2N4O
- 纯度：99%
- 分子量：278.261
产品详情
pd_meltingpoint:178-182 °C(Solv: isopropanol (67-63-0))
- Molecular Formula:C13H12F2N4O
- Molecular Weight:278.261
- Melting Point:178-182 °C(Solv: isopropanol (67-63-0))
- Boiling Point:522.5±60.0 °C(Predicted)
- PKA:11.15±0.29(Predicted)
- PSA：74.73000
- Density:1.32±0.1 g/cm3(Predicted)
- LogP:1.60378
170862-36-9 Relevant articles
AN IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOLE DERIVATIVES
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Page/Page column 21-22, (2021/12/31)
The present invention relates to an impr...
Method for manufacturing isavuconazole or ravuconazole
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Paragraph 0075; 0076, (2017/08/27)
The invention provides a method for manu...
An enantioselective synthesis of the key intermediate for triazole antifungal agents; Application to the catalytic asymmetric synthesis of efinaconazole (jublia)
Tamura, Keiji,Kumagai, Naoya,Shibasaki, Masakatsu
, p. 3272 - 3278 (2014/05/06)
A new synthetic route, the shortest repo...
Improved chiral synthesis of ravuconazole
Xu, Lin,Muller, Marc R.,Yu, Xiong,Zhu, Bao-Quan
experimental part, p. 1611 - 1625 (2009/10/17)
A short, elegant, and high yielding synt...
170862-36-9 Process route
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3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile
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- 170862-36-9
(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile
| Conditions | Yield |
|---|---|
|
With [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; In methanol; tert-butyl methyl ether; toluene; at 60 ℃; for 1h;
|
34.7% |
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- 219872-85-2
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanamide
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- 170862-36-9
(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile
| Conditions | Yield |
|---|---|
|
With trichlorophosphate; at 40 ℃; for 3h;
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94.6% |
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With trichlorophosphate; In N,N-dimethyl-formamide; at 10 - 35 ℃; Temperature; Solvent;
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85 g |
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With trichlorophosphate; In N,N-dimethyl-formamide; at 10 - 35 ℃; Temperature; Solvent;
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85 g |
170862-36-9 Upstream products
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5804-85-3
diethylaluminium cyanide
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124627-86-7
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole
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75-86-5
2-hydroxy-2-methylpropanenitrile
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135270-13-2
1-(((2R,3R)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole
170862-36-9 Downstream products
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170863-34-0
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide
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170862-56-3
(2R,3R)-3-(2,4-Difluoro-phenyl)-3-hydroxy-2-methyl-4-[1,2,4]triazol-1-yl-butyraldehyde
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170863-35-1
(2R,3R)-2-(2,4-Difluoro-phenyl)-3-[4-(4-methylsulfanyl-phenyl)-thiazol-2-yl]-1-[1,2,4]triazol-1-yl-butan-2-ol
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368421-60-7
4-{2-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-thiazol-4-yl}-thiobenzamide
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