142217-77-4
- 产品名称：(1S,2S,3S,5S)-5-(2-氨基-6-苄氧基-9H-嘌呤-9-基)-3-苄氧基-2-苄氧基甲基环戊醇
- 分子式：C32H33N5O4
- 纯度：99%
- 分子量：551.645
产品详情
外观:Colorless transparent liquid
- Molecular Formula:C32H33N5O4
- Molecular Weight:551.645
- Appearance/Colour:Colorless transparent liquid
- Refractive Index:1.67
- Boiling Point:780.5 °C at 760 mmHg
- PKA:13.88±0.70(Predicted)
- Flash Point:425.8 °C
- PSA：117.54000
- Density:1.33 g/cm3
- LogP:5.29280
(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol(Cas 142217-77-4) Usage
InChI:InChI=1/C32H33N5O4/c33-32-35-30-28(31(36-32)41-19-24-14-8-3-9-15-24)34-21-37(30)26-16-27(40-18-23-12-6-2-7-13-23)25(29(26)38)20-39-17-22-10-4-1-5-11-22/h1-15,21,25-27,29,38H,16-20H2,(H2,33,35,36)/t25-,26+,27+,29+/m1/s1
142217-77-4 Relevant articles
Method for synthesizing Entecavir intermediate
-
Paragraph 0031-0034, (2020/03/05)
The invention relates to a method for sy...
Method for production of entecavir intermediate IV
-
Paragraph 0013-0014; 0015-0016; 0017-0018, (2018/03/24)
The invention discloses a method for saf...
BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
Bisacchi,Chao,Bachard,Daris,Innaimo,Jacobs,Kocy,Lapointe,Martel,Merchant,Slusarchyk,Sundeen,Young,Colonno,Zahler
, p. 127 - 132 (2007/10/03)
BMS-200475, a never carbocyclic analog o...
Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
-
, (2008/06/13)
Antiviral activity is exhibited by compo...
142217-77-4 Process route
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- 110567-22-1
(2R,3S)-benzyloxy-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexane
-
- 19916-73-5
2-Amino-6-benzyloxypurine
-
![[1S-(1α,2β,3α,5β)]-5-(2-amino-6-benzyloxy-9H-purin-9-yl)-3-benzyloxy-2-(benzyloxy)methyl-cyclopentanol](/upload/2023/9/3601bf5a-4eb5-4451-ba0a-818d654c5685.png)
- 142217-77-4
[1S-(1α,2β,3α,5β)]-5-(2-amino-6-benzyloxy-9H-purin-9-yl)-3-benzyloxy-2-(benzyloxy)methyl-cyclopentanol
| Conditions | Yield |
|---|---|
|
With lithium hydride; In N,N-dimethyl-formamide; at 125 ℃; for 2h;
|
60% |
|
2-Amino-6-benzyloxypurine; With lithium hydride; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 0.416667h;
(2R,3S)-benzyloxy-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexane; In N,N-dimethyl-formamide; at 60 - 125 ℃; for 2.25h;
|
51.18% |
|
With acetic acid; In N-methyl-acetamide; methanol; ethanol; dichloromethane; chloroform;
|
|
|
With tetrabutylammomium bromide; potassium hydroxide; In toluene; at 80 ℃; for 6h; Temperature; Reagent/catalyst;
|
6 g |
-
- 3587-60-8
Benzyloxymethyl chloride
-
- 142217-77-4
[1S-(1α,2β,3α,5β)]-5-(2-amino-6-benzyloxy-9H-purin-9-yl)-3-benzyloxy-2-(benzyloxy)methyl-cyclopentanol
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 5 steps
1: tetrahydrofuran / -78 - -65 °C
2: 1.) diisopinylcampheylborane (prepared from (+)-α-pinene), 2.) aq. NaOH, H2O2 / 1.) THF, -65 to -78 deg C
3: VO(acac)2, t-BuOOH / CH2Cl2
4: NaH, Bu4NI / dimethylformamide
5: 60 percent / LiH / dimethylformamide / 2 h / 125 °C
With tert.-butylhydroperoxide; sodium hydroxide; bis(acetylacetonate)oxovanadium; (-)-diisopinocampheylborane; dihydrogen peroxide; tetra-(n-butyl)ammonium iodide; lithium hydride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
|
142217-77-4 Upstream products
-
110567-22-1
(2R,3S)-benzyloxy-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexane
-
19916-73-5
2-Amino-6-benzyloxypurine
-
3587-60-8
Benzyloxymethyl chloride
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39939-07-6
5-(benzyloxymethyl)cyclopentadiene
142217-77-4 Downstream products
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142217-78-5
(1S,2S,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-purin-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanol
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1006053-47-9
[1S-(1α,2β,3α,5β)]-5-(2-acetylamino-6-benzyloxy-9H-purin-9-yl)-3-benzyloxy-2-(benzyloxy)methyl-cyclopentanol
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142217-80-9
6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylidenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
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142217-79-6
(2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone
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