142217-81-0
- 产品名称：2-氨基-1,9-二氢-9-[(1S,3R,4S)-4-苄氧基-3-苄氧基甲基-2-亚甲基环戊基]-6H-嘌呤-6-酮
- 分子式：C26H27N5O3
- 纯度：99%
- 分子量：457.532
产品详情
- Molecular Formula:C26H27N5O3
- Molecular Weight:457.532
- Refractive Index:1.679
- PKA:9?+-.0.20(Predicted)
- PSA：108.05000
- Density:1.34 g/cm3
- LogP:4.20240
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one(Cas 142217-81-0) Usage
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Chemical Properties |
White powder |
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Uses |
3’5’Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent, Entecavir (E558900). |
InChI:InChI=1/C26H27N5O3/c1-17-20(15-33-13-18-8-4-2-5-9-18)22(34-14-19-10-6-3-7-11-19)12-21(17)31-16-28-23-24(31)29-26(27)30-25(23)32/h2-11,16,20-22H,1,12-15H2,(H3,27,29,30,32)/t20-,21-,22-/m0/s1
142217-81-0 Relevant articles
Improved entecavir intermediate synthesis process and improved entecavir synthesis process
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Paragraph 0017; 0053; 0055; 0064; 0065; 0070, (2020/10/14)
The invention discloses an improved ente...
Entecavir preparation method using Boc protection group
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Paragraph 0044; 0045; 0046, (2018/07/10)
The invention belongs to the field of dr...
A New Route for the Synthesis of Entecavir
Wang, Shan-chun,Zhang, Xi-quan,Gu, Hong-mei,Zhu, Xue-yan,Guo, Ya-jun
, p. 568 - 574 (2017/12/12)
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A method for preparation of a purine derivative and intermediates
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, (2016/12/01)
The invention discloses a preparation me...
142217-81-0 Process route
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C38H41N5O5
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![2-amino-1,9-dihydro-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-6H-purin-6-one](/upload/2023/9/66d412df-b04a-42dd-8e0c-a5baf372960e.png)
- 142217-81-0
2-amino-1,9-dihydro-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-6H-purin-6-one
| Conditions | Yield |
|---|---|
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With hydrogenchloride; In tetrahydrofuran; methanol; water; at 50 ℃; for 2.5h;
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92% |
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3,6-diamino-4-(((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)amino)pyridin-2(1H)-one
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- 122-51-0
orthoformic acid triethyl ester
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- 142217-81-0
2-amino-1,9-dihydro-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-6H-purin-6-one
| Conditions | Yield |
|---|---|
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With hydrogenchloride; In methanol; water; at 25 - 50 ℃; for 12.16h; Large scale;
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53% |
142217-81-0 Upstream products
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142217-80-9
6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylidenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
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3587-60-8
Benzyloxymethyl chloride
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39939-07-6
5-(benzyloxymethyl)cyclopentadiene
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110567-22-1
(2R,3S)-benzyloxy-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexane
142217-81-0 Downstream products
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142217-69-4
entecavir
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