157322-83-3
- 产品名称：2-((2R,4aS,6S,7R,8S,8aS)-7,8-二((叔丁基二甲基硅基)氧)-6-((S,E)-1-((叔丁基二甲基硅基)氧)-3-碘代)八氢吡喃[3,2-b]吡喃-2-基)乙酸甲酯
- 分子式：C32H63IO7Si3
- 纯度：99%
- 分子量：771
产品详情
- Molecular Formula:C32H63IO7Si3
- Molecular Weight:771
- Boiling Point:608.3±55.0 °C(Predicted)
- PSA：72.45000
- Density:1.14±0.1 g/cm3(Predicted)
- LogP:8.98440
157322-83-3 Relevant articles
PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF
-
, (2017/10/31)
The present application relate to proces...
INTERMEDIATES FOR THE PREPARATION OF HALICHONDRIN B
-
Page/Page column 80, (2010/02/15)
The present invention provides macrocycl...
Synthetic studies on halichondrins: A practical synthesis of the C.1-C.13 segment
Stamos, Dean P.,Kishi, Yoshito
, p. 8643 - 8646 (2007/10/03)
A practical, scalable synthesis of the C...
157322-83-3 Process route
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![{(2R,4aS,6S,7R,8S,8aS)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-[(E)-(S)-1-(tert-butyl-dimethyl-silanyloxy)-3-trimethylsilanyl-allyl]-octahydro-pyrano[3,2-b]pyran-2-yl}-acetic acid methyl ester](/upload/2023/9/f5071bf7-f2e7-4ee6-ad64-397878f78eb7.png)
- 185411-11-4
{(2R,4aS,6S,7R,8S,8aS)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-[(E)-(S)-1-(tert-butyl-dimethyl-silanyloxy)-3-trimethylsilanyl-allyl]-octahydro-pyrano[3,2-b]pyran-2-yl}-acetic acid methyl ester
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![methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate](/upload/2023/9/2b4b9d14-da29-44b6-b514-99d764db6f65.png)
- 157322-83-3
methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate
| Conditions | Yield |
|---|---|
|
With N-iodo-succinimide; tert-butyldimethylsilyl chloride; In toluene; acetonitrile; at 30 ℃; for 22h;
|
89.5% |
|
With N-iodo-succinimide; In acetonitrile; Ambient temperature;
|
80% |
-
- 69739-34-0
t-butyldimethylsiyl triflate
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![methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-hydroxy-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate](/upload/2023/9/aa58e3dc-7f4d-41bd-82e5-be6afb145f70.png)
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methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-hydroxy-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate
-
- 157322-83-3
methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate
| Conditions | Yield |
|---|---|
|
With 2,6-dimethylpyridine; In dichloromethane; at -5 - 0 ℃; for 3h;
|
5.4 g |
157322-83-3 Upstream products
-
185411-11-4
{(2R,4aS,6S,7R,8S,8aS)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-[(E)-(S)-1-(tert-butyl-dimethyl-silanyloxy)-3-trimethylsilanyl-allyl]-octahydro-pyrano[3,2-b]pyran-2-yl}-acetic acid methyl ester
-
69739-34-0
t-butyldimethylsiyl triflate
-
871360-33-7
[(2R,4aS,6S,7S,8R,8aR)-7,8-Dihydroxy-6-((E)-(S)-1-hydroxy-3-trimethylsilanyl-allyl)-octahydro-pyrano[3,2-b]pyran-2-yl]-acetic acid methyl ester
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871360-14-4
C18H26O7
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