产品详情
- Molecular Formula:C40H47 N O15
- Molecular Weight:781.811
- PSA：196.33000
- LogP:3.16670
114869-97-5 Relevant articles
Synthesis of heparin partial structures and their binding activities to platelets
Koshida, Shuhei,Suda, Yasuo,Sobel, Michael,Ormsby, Julie,Kusumoto, Shoichi
, p. 3127 - 3132 (2007/10/03)
A synthetic pentasaccharide correspondin...
SYNTHESIS OF HEPARIN FRAGMENTS: A METHYL α-PENTANOSIDE WITH HIGH AFFINITY FOR ANTITHROMBIN III
Petitou, Maurice,Duchaussoy, Philippe,Lederman, Isidore,Choay, Jean,Jaquinet, Jean-Claude,et al.
, p. 67 - 76 (2007/10/02)
The synthesis is described of the methyl...
114869-97-5 Process route
-
- 114869-96-4
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-4-O-(methyl 2-O-acetyl-3-O-benzyl-4-O-chloroacetyl-α-L-idopyranosyluronate)-α-D-glucopyranoside
-
- 114869-97-5
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-4-O-(methyl 2-O-acetyl-3-O-benzyl-α-L-idopyranosyluronate)-α-D-glucopyranoside
| Conditions | Yield |
|---|---|
|
With 2,6-dimethylpyridine; dithiocarbonic acid hydrazide; acetic acid; In methanol; dichloromethane; for 0.166667h;
|
85% |
-
- 87907-35-5
methyl 2-
-
- 114869-97-5
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-4-O-(methyl 2-O-acetyl-3-O-benzyl-α-L-idopyranosyluronate)-α-D-glucopyranoside
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 9 steps
1: pyridine / CH2Cl2
2: 75 percent / Sn(OTf)2 / CH2Cl2 / 0 °C
3: NaOMe; MeOH
4: CSA / acetone
5: DMAP; pyridine / CH2Cl2
6: aq. AcOH
7: 2,2,6,6-tetramethyl-1-piperidinyloxy radical; NaClO; KBr
8: NaClO2; aq. NaH2PO4 / 2-methyl-propan-2-ol
With pyridine; methanol; dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; sodium dihydrogenphosphate; tin(II) trifluoromethanesulfonate; camphor-10-sulfonic acid; sodium methylate; acetic acid; potassium bromide; In dichloromethane; acetone; tert-butyl alcohol; 1: Acetylation / 2: Glycosidation / 3: Deacetylation / 4: Acetalization / 5: Acetylation / 6: Hydrolysis / 7: Oxidation / 8: Oxidation / 9: Esterification;
|
|
|
Multi-step reaction with 3 steps
1: 59 percent / CH2Cl2 / Heating
2: 1) 2,6-dimethylpyridinium perchlorate / 1) chlorobenzene, 20 min, reflux, 2) reflux, 15 min
3: 85 percent / 2,6-dimethylpyridine, hydrazinedithiocarbonate, acetic acid / methanol; CH2Cl2 / 0.17 h
With 2,6-dimethylpyridine; dithiocarbonic acid hydrazide; 2,6-lutidinium perchlorate; acetic acid; In methanol; dichloromethane;
|
114869-97-5 Upstream products
-
114869-96-4
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-4-O-(methyl 2-O-acetyl-3-O-benzyl-4-O-chloroacetyl-α-L-idopyranosyluronate)-α-D-glucopyranoside
-
256486-94-9
methyl 6-O-acetyl-4-O-[2-O-acetyl-3-O-(phenylmethyl)-α-L-idopyranuronosyl)-2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-α-D-glucopyranoside
-
18107-18-1
diazomethyl-trimethyl-silane
-
3006-58-4
2-carbobenzyloxyamino-2-deoxy-D-glucopyranose
114869-97-5 Downstream products
-
155630-80-1
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-4-O-(methyl 2-O-acetyl-3-O-benzyl-4-O-p-methoxybenzyl-α-L-idopyranosyluronate)-α-D-glucopyranoside
-
256348-59-1
5-acetoxy-3-(6-acetoxymethyl-3-azido-4-benzyloxy-5-methoxy-tetrahydro-pyran-2-yloxy)-6-(2-acetoxymethyl-4-benzyloxy-5-benzyloxycarbonylamino-6-methoxy-tetrahydro-pyran-3-yloxy)-4-benzyloxy-tetrahydro-pyran-2-carboxylic acid methyl ester
-
1266553-86-9
methyl(methyl 2-O-acetyl-3-O-benzyl-4-O-levulinoyl-α-L-idopyranosyluronate)-(1→4)-6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
-
1266553-87-0
methyl(methyl 2-O-acetyl-3-O-benzyl-4-O-levulinoyl-α-L-idopyranosyluronate)-(1→4)-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
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