74874-08-1
- 产品名称：1-[2-氨基-5-[[亚氨基(硝基氨基)甲基]氨基]-1-氧戊基]-4-甲基-2-哌啶羧酸乙酯盐酸盐,[2R-[1(S*),2Α,4Β]]
- 分子式：C15H28N6O5.HCl
- 纯度：99%
- 分子量：408.885
产品详情
pd_meltingpoint:174-177°C
- Molecular Formula:C15H28N6O5*ClH
- Molecular Weight:408.885
- Melting Point:174-177°C
- PSA：166.36000
- LogP:2.43470
Ethyl (2R,4R)-1-(Nitroglycerine-nitro-L-arginyl)-4-methyl-piperidinecarboxylate hydrochloride(Cas 74874-08-1) Usage
|
Chemical Properties |
Off White Solid |
|
Uses |
Argatroban intermediate. |
InChI:InChI=1/C15H28N6O5.ClH/c1-3-26-14(23)12-9-10(2)6-8-20(12)13(22)11(16)5-4-7-18-15(17)19-21(24)25;/h10-12H,3-9,16H2,1-2H3,(H3,17,18,19);1H/t10-,11?,12-;/m1./s1
74874-08-1 Relevant articles
Thrombin inhibitors. 3. Carboxyl-containing amide derivatives of N alpha-substituted L-arginine.
Kikumoto,Tamao,Ohkubo,Tezuka,Tonomura,Okamoto,Hijikata
, p. 1293 - 1299 (2007/10/02)
A series of N alpha-(arylsulfonyl)-L-arg...
74874-08-1 Process route
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- 74863-81-3,74874-07-0
ethyl 1-
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- 69129-28-8,74874-08-1
ethyl 4-methyl-1-(Nω-nitro-L-arginyl)piperidinecarboxylate hydrochloride
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; In ethyl acetate; for 3h;
|
-
- 66937-93-7,42205-75-4
4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester
-
- 69129-28-8,74874-08-1
ethyl 4-methyl-1-(Nω-nitro-L-arginyl)piperidinecarboxylate hydrochloride
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: tetrahydrofuran / 1.) -20 deg C, 10 min, 2.) RT, 1 h
2: HCl / ethyl acetate / 3 h
With hydrogenchloride; In tetrahydrofuran; ethyl acetate;
|
74874-08-1 Upstream products
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74863-81-3
ethyl 1-
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66937-93-7
4(R)-Methylpiperidine-2(R)-carboxylic acid ethyl ester
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2188-18-3
Boc-Arg(NO2)-OH
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