142217-80-9
- Product Name：6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
- Structural Formula：C53H49N5O4
- Purity：99%
- Molecular Weight：820.003
Product Details
Manufacturer In Bulk Supply Pharmaceutical Grade 6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine 142217-80-9
- Molecular Formula:C53H49N5O4
- Molecular Weight:820.003
- Refractive Index:1.635
- PKA:3.08±0.30(Predicted)
- PSA：92.55000
- Density:1.19 g/cm3
- LogP:10.81030
6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine(Cas 142217-80-9) Usage
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Chemical Properties |
White powder |
InChI:InChI=1/C53H49N5O4/c1-38-46(36-60-33-39-18-8-3-9-19-39)48(61-34-40-20-10-4-11-21-40)32-47(38)58-37-54-49-50(58)55-52(56-51(49)62-35-41-22-12-5-13-23-41)57-53(42-24-14-6-15-25-42,43-26-16-7-17-27-43)44-28-30-45(59-2)31-29-44/h3-31,37,46-48H,1,32-36H2,2H3,(H,55,56,57)/t46-,47+,48?/m0/s1
142217-80-9 Relevant articles
Synthetic method of entecavir intermediate
-
Paragraph 0010; 0029-0040, (2020/02/14)
The invention relates to a synthetic met...
Improved entecavir intermediate synthesis process and improved entecavir synthesis process
-
, (2020/10/14)
The invention discloses an improved ente...
Entecavir industrial preparation method (by machine translation)
-
Paragraph 0028; 0029; 0030; 0031; 0032; 0033; 0034, (2018/07/15)
The invention discloses entecavir indust...
BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
Bisacchi,Chao,Bachard,Daris,Innaimo,Jacobs,Kocy,Lapointe,Martel,Merchant,Slusarchyk,Sundeen,Young,Colonno,Zahler
, p. 127 - 132 (2007/10/03)
BMS-200475, a never carbocyclic analog o...
142217-80-9 Process route
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![(2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone](/upload/2023/9/52d34080-52d4-4ad3-a832-0fa766e68441.png)
- 142217-79-6
(2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone
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- 142217-80-9,1354695-79-6
6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylidenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
| Conditions | Yield |
|---|---|
|
With hydrogenchloride; titanium tetrachloride; zinc; In tetrahydrofuran; dichloromethane; water; at -30 - 20 ℃; Inert atmosphere; Sealed tube; Molecular sieve;
|
88% |
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nysted reagent
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- 142217-79-6
(2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone
-
- 142217-80-9,1354695-79-6
6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylidenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
| Conditions | Yield |
|---|---|
|
nysted reagent; With titanium(IV) isopropylate; titanium tetrachloride; In tetrahydrofuran; dichloromethane; at -70 - -60 ℃; for 1h; Inert atmosphere;
(2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone; In tetrahydrofuran; dichloromethane; at -60 - 20 ℃; Temperature; Inert atmosphere;
|
90% |
142217-80-9 Upstream products
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142217-79-6
(2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone
-
74-95-3
1,1-dibromomethane
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3587-60-8
Benzyloxymethyl chloride
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39939-07-6
5-(benzyloxymethyl)cyclopentadiene
142217-80-9 Downstream products
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142217-81-0
2-amino-1,9-dihydro-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-6H-purin-6-one
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142217-69-4
entecavir
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1354695-82-1
C26H27N5O3
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