157322-83-3
- Product Name：Methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate
- Structural Formula：C32H63IO7Si3
- Purity：99%
- Molecular Weight：771
Product Details
Factory supply commercial production commercial production intermediate 157322-83-3 manufacturer
- Molecular Formula:C32H63IO7Si3
- Molecular Weight:771
- Boiling Point:608.3±55.0 °C(Predicted)
- PSA：72.45000
- Density:1.14±0.1 g/cm3(Predicted)
- LogP:8.98440
157322-83-3 Relevant articles
PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF
-
, (2017/10/31)
The present application relate to proces...
INTERMEDIATES FOR THE PREPARATION OF HALICHONDRIN B
-
Page/Page column 80, (2010/02/15)
The present invention provides macrocycl...
Synthetic studies on halichondrins: A practical synthesis of the C.1-C.13 segment
Stamos, Dean P.,Kishi, Yoshito
, p. 8643 - 8646 (2007/10/03)
A practical, scalable synthesis of the C...
157322-83-3 Process route
-
![{(2R,4aS,6S,7R,8S,8aS)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-[(E)-(S)-1-(tert-butyl-dimethyl-silanyloxy)-3-trimethylsilanyl-allyl]-octahydro-pyrano[3,2-b]pyran-2-yl}-acetic acid methyl ester](/upload/2023/9/11aad30a-b8ae-4dba-9aae-8d27de863a00.png)
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185411-11-4
{(2R,4aS,6S,7R,8S,8aS)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-[(E)-(S)-1-(tert-butyl-dimethyl-silanyloxy)-3-trimethylsilanyl-allyl]-octahydro-pyrano[3,2-b]pyran-2-yl}-acetic acid methyl ester
-
![methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate](/upload/2023/9/25ff6279-3102-48a0-9046-57a418e636df.png)
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157322-83-3
methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate
| Conditions | Yield |
|---|---|
|
With
N-iodo-succinimide; tert-butyldimethylsilyl chloride;
In
toluene; acetonitrile;
at 30 ℃;
for 22h;
|
89.5% |
|
With
N-iodo-succinimide;
In
acetonitrile;
Ambient temperature;
|
80% |
-
-
69739-34-0
t-butyldimethylsiyl triflate
-
![methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-hydroxy-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate](/upload/2023/9/4130efa2-c9fb-4bfc-9813-bc7227b34059.png)
-
methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-hydroxy-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate
-
-
157322-83-3
methyl 2-((2R,4aS,6S,7R,8S,8aS)-7,8-bis((tert-butyldimethylsilyl)oxy)-6-((S,E)-1-((tert-butyldimethylsilyl)oxy)-3-iodoallyl)octahydropyrano[3,2-b]pyran-2-yl)acetate
| Conditions | Yield |
|---|---|
|
With
2,6-dimethylpyridine;
In
dichloromethane;
at -5 - 0 ℃;
for 3h;
|
5.4 g |
157322-83-3 Upstream products
-
185411-11-4
{(2R,4aS,6S,7R,8S,8aS)-7,8-Bis-(tert-butyl-dimethyl-silanyloxy)-6-[(E)-(S)-1-(tert-butyl-dimethyl-silanyloxy)-3-trimethylsilanyl-allyl]-octahydro-pyrano[3,2-b]pyran-2-yl}-acetic acid methyl ester
-
69739-34-0
t-butyldimethylsiyl triflate
-
871360-33-7
[(2R,4aS,6S,7S,8R,8aR)-7,8-Dihydroxy-6-((E)-(S)-1-hydroxy-3-trimethylsilanyl-allyl)-octahydro-pyrano[3,2-b]pyran-2-yl]-acetic acid methyl ester
-
871360-14-4
C18H26O7
