241479-74-3
- Product Name：(αS,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanenitrile
- Structural Formula：C13H12F2N4O
- Purity：99%
- Molecular Weight：278.261
Product Details
Factory supply Pharmaceutical Intermediates (αS,βR)-β-(2,5-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanenitrile 241479-74-3 manufacturer
- Molecular Formula:C13H12F2N4O
- Molecular Weight:278.261
- Boiling Point:522.5±60.0 °C(Predicted)
- PKA:10.95±0.29(Predicted)
- PSA：74.73000
- Density:1.32±0.1 g/cm3(Predicted)
- LogP:1.60378
241479-74-3 Relevant articles
AN IMPROVED PROCESS FOR THE PREPARATION OF TRIAZOLE DERIVATIVES
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, (2021/12/31)
The present invention relates to an impr...
Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents
Feng, Xiaoming,He, Qianwen,Liu, Xiaohua,Zhang, Dong,Zhang, Fengcai
, p. 6961 - 6966 (2021/09/11)
An enantioselective epoxidation of α-sub...
Preparation method of isavuconazole intermediate
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Paragraph 0079-0088, (2019/12/09)
The invention provides a preparation met...
Method for manufacturing isavuconazole or ravuconazole
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Paragraph 0055; 0056; 0058; 0061; 0063; 0064-0067; 0078, (2017/08/27)
The invention provides a method for manu...
241479-74-3 Process route
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3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl) butyronitrile
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241479-74-3
(2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile
| Conditions | Yield |
|---|---|
|
With
[(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid;
In
methanol; tert-butyl methyl ether; toluene;
at 60 ℃;
for 1h;
Concentration;
Temperature;
|
84.7% |
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![(2S,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane](/upload/2023/9/7504e934-2238-4734-956e-a297d7054e57.png)
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(2S,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane
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7677-24-9
trimethylsilyl cyanide
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241479-74-3
(2S,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butyronitrile
| Conditions | Yield |
|---|---|
|
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 63 - 68 ℃;
for 26h;
Solvent;
Temperature;
|
94.9% |
241479-74-3 Upstream products
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241479-73-2
(2R,3S)-2-(2,5-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)-methyl]-oxirane
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75-86-5
2-hydroxy-2-methylpropanenitrile
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7677-24-9
trimethylsilyl cyanide
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60468-36-2
α-chloro-2',5'-difluoroacetophenone
241479-74-3 Downstream products
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241479-67-4
Isavuconazole
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1286730-01-5
(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide hydrogensulphate
Relevant Products
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3,3A,6,6A-TETRAHYDROCYCLOPENTA[B]FURAN-2-ONECAS：34638-25-0
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