338990-31-1
- 产品名称：N-甲基-N-(3-[((N-叔丁氧羰基-N-甲基氨基)乙酰氧基)甲基]吡啶-2-基)氨基甲酸(1-氯乙基)酯
- 分子式：C18H26ClN3O6
- 纯度：99%
- 分子量：415.874
产品详情
- Molecular Formula:C18H26ClN3O6
- Molecular Weight:415.874
- Boiling Point:507.3±50.0 °C(Predicted)
- PKA:2.50±0.10(Predicted)
- PSA：98.27000
- Density:1.254±0.06 g/cm3(Predicted)
- LogP:3.14930
338990-31-1 Relevant articles
Prodrugs of baloxvir and derivatives thereof and preparation method and application of prodrugs
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Paragraph 0047-0050, (2021/05/05)
The present invention provides a compoun...
Preparation method of liconazole sulfate and intermediate thereof (by machine translation)
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Paragraph 0122-0124, (2019/12/25)
The preparation method disclosed by the ...
INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
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, (2019/07/20)
The present invention provides a compoun...
Preparation method of [N-methyl-pyridine-2-yl] carbamate-1-ethyl chloride
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Paragraph 0042; 0043, (2017/01/26)
The invention relates to a preparation m...
338990-31-1 Process route
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- 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester
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(2-(methylamino)pyridin-3-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
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![N-methyl N-(3-[((N-tert-butoxycarbonyl-N-methylamino)acetoxy)methyl]pyridin-2-yl)carbamic acid (1-chloroethyl) ester](/upload/2023/9/414eb821-0bb1-45b7-a01d-a978ec204cbe.png)
- 338990-31-1
N-methyl N-(3-[((N-tert-butoxycarbonyl-N-methylamino)acetoxy)methyl]pyridin-2-yl)carbamic acid (1-chloroethyl) ester
| Conditions | Yield |
|---|---|
|
With sodium carbonate; In dichloromethane; at 0 - 5 ℃; for 8.5h;
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100% |
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With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 ℃; for 2h;
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80% |
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- 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester
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- 13734-36-6
N-(tert-butoxycarbonyl)sarcosine
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- 32399-12-5
2-(N-methylamino)-3-hydroxymethylpyridine
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- 338990-31-1
N-methyl N-(3-[((N-tert-butoxycarbonyl-N-methylamino)acetoxy)methyl]pyridin-2-yl)carbamic acid (1-chloroethyl) ester
| Conditions | Yield |
|---|---|
|
carbonochloridic acid 1-chloro-ethyl ester; 2-(N-methylamino)-3-hydroxymethylpyridine; With diisopropylamine; In dichloromethane; at -13 ℃; for 2h;
N-(tert-butoxycarbonyl)sarcosine; With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at -7 ℃; for 2.16667h;
|
72.9% |
|
carbonochloridic acid 1-chloro-ethyl ester; 2-(N-methylamino)-3-hydroxymethylpyridine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -13 ℃; for 1h;
N-(tert-butoxycarbonyl)sarcosine; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -7 ℃; for 2h;
|
64% |
338990-31-1 Upstream products
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13734-36-6
N-(tert-butoxycarbonyl)sarcosine
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49609-84-9
2-Chloronicotinoyl chloride
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2942-59-8
2-chloronicotinic acid
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32399-12-5
2-(N-methylamino)-3-hydroxymethylpyridine
338990-31-1 Downstream products
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338990-63-9
1-[[N-methyl-N-3-[(t-butoxycarbonylmethylamino)acetoxymethyl]pyridin-2-yl]carbamoyloxy]ethyl-1-[(2R,3R)-2-(2,5-difluorophenyl)-2-hydroxy-3-[4-(4-cyanophenyl)thiazol-2-yl]butyl]-1H-[1,2,4]triazol-4-ium chloride
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946075-13-4
1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl[3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl]-1H-1,2,4-triazol-4-ium hydrogensulfate
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