产品详情
- Molecular Formula:C35H35F2N8O5S*HO4S
- Molecular Weight:814.848
946075-13-4 Relevant articles
Method for preparing antifungal drug isavuconazonium sulfate
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Paragraph 0057-0085, (2021/01/30)
The invention discloses a method for pre...
Method for preparing isavuconazonium monosulfate by bisulfate/sulfate anion exchange technology
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Paragraph 0014; 0034-0035, (2019/10/01)
The invention discloses a method for pre...
Preparation method of liconazole sulfate and intermediate thereof (by machine translation)
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Paragraph 0129; 0133-0134, (2019/12/25)
The preparation method disclosed by the ...
Isavuconazole sulfate crystal and preparation method thereof
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Paragraph 0037-0047, (2017/05/10)
The invention relates to an isavuconazol...
946075-13-4 Process route
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- 338990-84-4
isavuconazonium chloride
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![1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl[3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl]-1H-1,2,4-triazol-4-ium hydrogensulfate](/upload/2023/9/89fea380-d5d7-41a9-baac-06eb82b03656.png)
- 946075-13-4
1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl[3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl]-1H-1,2,4-triazol-4-ium hydrogensulfate
| Conditions | Yield |
|---|---|
|
isavuconazonium chloride; With sodium hydrogencarbonate; In water; at 0 ℃; pH=7;
With sulfuric acid; dihydrogen peroxide; In methanol; water; at -5 ℃; for 0.5h; Temperature; Reagent/catalyst; Solvent;
|
76% |
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C40H43F2N8O7S(1+)*HO4S(1-)
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- 946075-13-4
1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4-[1-({methyl[3-({[2-(methylamino)acetyl]oxy}methyl)pyridin-2-yl]carbamoyl}oxy)ethyl]-1H-1,2,4-triazol-4-ium hydrogensulfate
| Conditions | Yield |
|---|---|
|
With sulfuric acid; In water; at 0 - 30 ℃; for 2h; Solvent;
|
57% |
946075-13-4 Upstream products
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338990-84-4
isavuconazonium chloride
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241479-67-4
Isavuconazole
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338990-31-1
N-methyl N-(3-[((N-tert-butoxycarbonyl-N-methylamino)acetoxy)methyl]pyridin-2-yl)carbamic acid (1-chloroethyl) ester
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