871360-12-2
- 产品名称：2-((3aR,4S,5aS,8R,9aS,9bS)-4-((R)-1,2-二羟乙基)八氢螺[[1,3]二氧杂环戊烯并[4,5-d]吡喃并[3,2-b]吡喃-2,1'-环己烷]-8-基)乙酸甲酯
- 分子式：
- 纯度：99%
- 分子量：386.442
产品详情
- Molecular Formula:C19H30O8
- Molecular Weight:386.442
- Boiling Point:557.0±45.0 °C(Predicted)
- PKA:13.35±0.20(Predicted)
- Density:1.31±0.1 g/cm3(Predicted)
871360-12-2 Relevant articles
Process development of halaven: Synthesis of the C1-C13 fragment from d -(-)-gulono-1,4-lactone
Chase, Charles E.,Fang, Francis G.,Lewis, Bryan M.,Wilkie, Gordon D.,Schnaderbeck, Matthew J.,Zhu, Xiaojie
, p. 323 - 326 (2013/04/10)
A 12-step kilogram-scale synthesis of th...
INTERMEDIATES FOR THE PREPARATION OF HALICHONDRIN B
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Page/Page column 76, (2010/02/15)
The present invention provides macrocycl...
871360-12-2 Process route
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- 871360-11-1
C25H36O11
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![methyl 2-((3aR,4S,5aS,8R,9aS,9bS)-4-((R)-1,2-dihydroxyethyl)octahydrospiro[[1,3]dioxolo[4,5-d]pyrano[3,2-b]pyran-2,1'-cyclohexan]-8-yl)acetate](/upload/2023/9/f480116c-3fd5-494a-bb29-405395de5e43.png)
- 871360-12-2
methyl 2-((3aR,4S,5aS,8R,9aS,9bS)-4-((R)-1,2-dihydroxyethyl)octahydrospiro[[1,3]dioxolo[4,5-d]pyrano[3,2-b]pyran-2,1'-cyclohexan]-8-yl)acetate
Conditions
| Conditions | Yield |
|---|---|
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With N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; acetic acid methyl ester; at 17 - 23 ℃; for 1.53333h; Product distribution / selectivity;
|
72% |
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With sodium methylate; In methanol; tert-butyl methyl ether; at 0 - 5 ℃; for 4h; Product distribution / selectivity;
|
38% |
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C23H34O10
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- 871360-12-2
methyl 2-((3aR,4S,5aS,8R,9aS,9bS)-4-((R)-1,2-dihydroxyethyl)octahydrospiro[[1,3]dioxolo[4,5-d]pyrano[3,2-b]pyran-2,1'-cyclohexan]-8-yl)acetate
Conditions
| Conditions | Yield |
|---|---|
|
With sodium methylate; In methanol; tert-butyl methyl ether; at 15 ℃;
|
62% |
871360-12-2 Upstream products
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871360-11-1
C25H36O11
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871360-09-7
C19H30O7
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871360-10-0
(3aR,4S,6S,7R,7aR)-4-((R)-1,2-diacetoxyethyl)tetrahydro-3aH-spiro[[1 ,3]dioxolo[4,5-c]pyran-2,1'-cyclohexane]-6,7-diyl diacetate
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185411-12-5
3-trimethylsilylpent-4-enoic acid methyl ester
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