114869-95-3
- Product Name：a-D-Glucopyranoside, methyl 2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-, 6-acetate
- Structural Formula：C24H29 N O8
- Purity：99%
- Molecular Weight：459.496
Product Details
Factory supply Pharmaceutical Grade a-D-Glucopyranoside, methyl 2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-, 6-acetate 114869-95-3 manufacturer
- Molecular Formula:C24H29 N O8
- Molecular Weight:459.496
- PSA：112.55000
- LogP:2.55300
114869-95-3 Relevant articles
PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
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, (2013/02/28)
Processes are disclosed for the synthesi...
Synthesis of heparin partial structures and their binding activities to platelets
Koshida, Shuhei,Suda, Yasuo,Sobel, Michael,Ormsby, Julie,Kusumoto, Shoichi
, p. 3127 - 3132 (2007/10/03)
A synthetic pentasaccharide correspondin...
SYNTHESIS OF HEPARIN FRAGMENTS: A METHYL α-PENTANOSIDE WITH HIGH AFFINITY FOR ANTITHROMBIN III
Petitou, Maurice,Duchaussoy, Philippe,Lederman, Isidore,Choay, Jean,Jaquinet, Jean-Claude,et al.
, p. 67 - 76 (2007/10/02)
The synthesis is described of the methyl...
114869-95-3 Process route
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- 87907-35-5
methyl 2-
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- 75-36-5
acetyl chloride
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- 114869-95-3
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
| Conditions | Yield |
|---|---|
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With pyridine; In dichloromethane; at -55 - -50 ℃; Inert atmosphere;
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- 1078691-95-8
(+)-D-glucosamine hydrochloride
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- 114869-95-3
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-α-D-glucopyranoside
| Conditions | Yield |
|---|---|
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Multi-step reaction with 6 steps
1: aq. Na2CO3
2: HCl
3: CSA / tetrahydrofuran
4: 78 percent / BaO; Ba(OH)2*8H2O / dimethylformamide
5: aq. AcOH
6: pyridine / CH2Cl2
With pyridine; hydrogenchloride; barium dihydroxide; camphor-10-sulfonic acid; sodium carbonate; acetic acid; barium(II) oxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Glycosidation / 3: Acetalization / 4: Alkylation / 5: Hydrolysis / 6: Acetylation;
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Multi-step reaction with 6 steps
1.1: sodium hydrogencarbonate / water / 20 °C / Industry scale
1.2: 3 h / 20 °C / Industry scale
2.1: hydrogenchloride / 14 h / 60 - 65 °C / Industry scale
3.1: zinc(II) chloride / 24 h / 20 °C / Industry scale
4.1: potassium hydroxide / 1,4-dioxane / 4 h / Reflux; Industry scale
5.1: water; acetic acid / 90 - 100 °C / Industry scale
6.1: pyridine / dichloromethane / -55 - -50 °C / Inert atmosphere
With pyridine; water; sodium hydrogencarbonate; acetic acid; potassium hydroxide; zinc(II) chloride; hydrogenchloride; In 1,4-dioxane; dichloromethane; water;
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114869-95-3 Upstream products
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2466-76-4
N-Acetylimidazole
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87907-35-5
methyl 2-
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108-24-7
acetic anhydride
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3006-58-4
2-carbobenzyloxyamino-2-deoxy-D-glucopyranose
114869-95-3 Downstream products
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114869-96-4
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-4-O-(methyl 2-O-acetyl-3-O-benzyl-4-O-chloroacetyl-α-L-idopyranosyluronate)-α-D-glucopyranoside
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115203-89-9
methyl 4-O-(2-O-acetyl-3-O-benzyl-4-o-levulinoyl-β-D-xylopyranosyl)-6-O-acetyl-3-O-benzyl-2-(benzyloxycarbonylamino)-2-deoxy-α-D-glucopyranoside
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256348-53-5
Acetic acid (2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-3-((2S,3R,4S,5R,6S)-3,5-diacetoxy-6-acetoxymethyl-4-benzyloxy-tetrahydro-pyran-2-yloxy)-6-methoxy-tetrahydro-pyran-2-ylmethyl ester
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114869-97-5
methyl 6-O-acetyl-3-O-benzyl-2-benzyloxycarbonylamino-2-deoxy-4-O-(methyl 2-O-acetyl-3-O-benzyl-α-L-idopyranosyluronate)-α-D-glucopyranoside
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(2R,4R)-4-Methylpiperidine-2-carboxylic acidCAS：74892-81-2
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